Solvent-tuning the collapse and helix formation time scales of λ(6-85)(*)

The λ(6-85)(*) pseudo-wild type of lambda repressor fragment is a fast two-state folder (k(f) ≈ 35 μsec(−1) at 58°C). Previously, highly stable λ(6-85)(*) mutants with k(f) > 30 μsec(−1) have been engineered to fold nearly or fully downhill. Stabilization of the native state by solvent tuning mig...

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Bibliographic Details
Main Authors: Dumont, Charles, Matsumura, Yoshitaka, Kim, Seung Joong, Li, Jinsong, Kondrashkina, Elena, Kihara, Hiroshi, Gruebele, Martin
Format: Artigo
Language:Inglês
Published: Blackwell Publishing 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242409/
https://ncbi.nlm.nih.gov/pubmed/17075136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062257406
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