Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2

Background:The adapter proteins SLP-76 and LAT have been shown to play critical roles in the activation of PLCγ2 in platelets downstream of GPVI/FcRγ and the C-type lectin receptor CLEC-2. SLP-76 is constitutively associated with the adapter Gads in platelets, which also binds to tyrosine phosphoryl...

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Bibliografiske detaljer
Main Authors: HUGHES, C E, AUGER, J M, McGLADE, J, EBLE, J A, PEARCE, A C, WATSON, S P
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2008
Fag:
Platelets
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710801/
https://ncbi.nlm.nih.gov/pubmed/18826392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2008.03166.x
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