Significant Hypo-Responsiveness to GPVI and CLEC-2 Agonists in Pre-Term and Full-Term Neonatal Platelets and following Immune Thrombocytopenia

Neonatal platelets are hypo-reactive to the tyrosine kinase-linked receptor agonist collagen. Here, we have investigated whether the hypo-responsiveness is related to altered levels of glycoprotein VI (GPVI) and integrin α2β1, or to defects in downstream signalling events by comparison to platelet a...

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Detalhes bibliográficos
Publicado no:Thromb Haemost
Main Authors: Hardy, Alexander T., Palma-Barqueros, Verónica, Watson, Stephanie K., Malcor, Jean-Daniel, Eble, Johannes A., Gardiner, Elizabeth E., Blanco, José E., Guijarro-Campillo, Rafael, Delgado, Juan L., Lozano, María L., Teruel-Montoya, Raúl, Vicente, Vicente, Watson, Steve P., Rivera, José, Ferrer-Marín, Francisca
Formato: Artigo
Idioma:Inglês
Publicado em: Schattauer GmbH 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202930/
https://ncbi.nlm.nih.gov/pubmed/29695020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0038-1646924
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