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The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells
Activated mast cells are a major source of the eicosanoids, prostaglandin (PG)D(2) and leukotriene (LT)C(4), which contribute to allergic responses. These eicosanoids are produced following the ERK1/2-dependent activation of cytosolic phospholipase A(2) (cPLA(2)), thus liberating arachidonic acid wh...
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| Hoofdauteurs: | , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2008
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2709775/ https://ncbi.nlm.nih.gov/pubmed/19017959 |
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