The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells

Activated mast cells are a major source of the eicosanoids, prostaglandin (PG)D(2) and leukotriene (LT)C(4), which contribute to allergic responses. These eicosanoids are produced following the ERK1/2-dependent activation of cytosolic phospholipase A(2) (cPLA(2)), thus liberating arachidonic acid wh...

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Hlavní autoři: Kuehn, Hye Sun, Swindle, Emily J., Kim, Mi-Sun, Beaven, Michael A., Metcalfe, Dean D., Gilfillan, Alasdair M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709775/
https://ncbi.nlm.nih.gov/pubmed/19017959
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