CD8+ Th17 Mediate Costimulation Blockade Resistant Allograft Rejection in T-bet Deficient Mice

While studying T helper (Th) responses induced by cardiac transplantation, we observed that mice deficient in the Th1 transcription factor T-bet (T-bet-/-) mount both Th1 and Th17 responses, while wild type (WT) recipients mount only Th1 responses. Cells producing both IFNγ and IL-17 were readily de...

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Main Authors: Burrell, Bryna E., Csencsits, Keri, Lu, Guanyi, Grabauskiene, Svetlana, Bishop, D. Keith
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709752/
https://ncbi.nlm.nih.gov/pubmed/18768845
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