Structure/Activity Relationship Studies of Small-Molecule Inhibitors of Wnt Response

Suppression of oncogenic Wnt-mediated signaling holds promise as an anti-cancer therapeutic strategy. We previously reported a novel class of small molecules (IWR-1/2, Inhibitors of Wnt Response) that antagonize Wnt signaling by stabilizing the Axin destruction complex. Herein, we present the result...

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Main Authors: Lu, Jianming, Ma, Zhiqiang, Hsieh, Jen-Chieh, Fan, Chih-Wei, Chen, Baozhi, Longgood, Jamie C., Williams, Noelle S., Amatruda, James F., Lum, Lawrence, Chen, Chuo
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709695/
https://ncbi.nlm.nih.gov/pubmed/19410457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.04.040
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