Requirement for XLF/Cernunnos in alignment-based gap filling by DNA polymerases λ and μ for nonhomologous end joining in human whole-cell extracts

XLF/Cernunnos is a core protein of the nonhomologous end-joining pathway of DNA double-strand break repair. To better define the role of Cernunnos in end joining, whole-cell extracts were prepared from Cernunnos-deficient human cells. These extracts effected little joining of DNA ends with cohesive...

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Bibliographic Details
Main Authors: Akopiants, Konstantin, Zhou, Rui-Zhe, Mohapatra, Susovan, Valerie, Kristoffer, Lees-Miller, Susan P., Lee, Kyung-Jong, Chen, David J., Revy, Patrick, de Villartay, Jean-Pierre, Povirk, Lawrence F.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
Subjects:
Nucleic Acids Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709571/
https://ncbi.nlm.nih.gov/pubmed/19420065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp283
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