Structural characterization of filaments formed by human Xrcc4–Cernunnos/XLF complex involved in nonhomologous DNA end-joining

Cernunnos/XLF is a core protein of the nonhomologous DNA end-joining (NHEJ) pathway that processes the majority of DNA double-strand breaks in mammals. Cernunnos stimulates the final ligation step catalyzed by the complex between DNA ligase IV and Xrcc4 (X4). Here we present the crystal structure of...

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Autori principali: Ropars, Virginie, Drevet, Pascal, Legrand, Pierre, Baconnais, Sonia, Amram, Jeremy, Faure, Guilhem, Márquez, José A., Piétrement, Olivier, Guerois, Raphaël, Callebaut, Isabelle, Le Cam, Eric, Revy, Patrick, de Villartay, Jean-Pierre, Charbonnier, Jean-Baptiste
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150875/
https://ncbi.nlm.nih.gov/pubmed/21768349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1100758108
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