Novel Transthyretin Amyloid Fibril Formation Inhibitors: Synthesis, Biological Evaluation, and X-Ray Structural Analysis

Transthyretin (TTR) is one of thirty non-homologous proteins whose misfolding, dissociation, aggregation, and deposition is linked to human amyloid diseases. Previous studies have identified that TTR amyloidogenesis can be inhibited through stabilization of the native tetramer state by small molecul...

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Bibliografische gegevens
Hoofdauteurs: Palaninathan, Satheesh K., Mohamedmohaideen, Nilofar N., Orlandini, Elisabetta, Ortore, Gabriella, Nencetti, Susanna, Lapucci, Annalina, Rossello, Armando, Freundlich, Joel S., Sacchettini, James C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2009
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709434/
https://ncbi.nlm.nih.gov/pubmed/19621084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006290
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