Novel Transthyretin Amyloid Fibril Formation Inhibitors: Synthesis, Biological Evaluation, and X-Ray Structural Analysis

Transthyretin (TTR) is one of thirty non-homologous proteins whose misfolding, dissociation, aggregation, and deposition is linked to human amyloid diseases. Previous studies have identified that TTR amyloidogenesis can be inhibited through stabilization of the native tetramer state by small molecul...

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Main Authors: Palaninathan, Satheesh K., Mohamedmohaideen, Nilofar N., Orlandini, Elisabetta, Ortore, Gabriella, Nencetti, Susanna, Lapucci, Annalina, Rossello, Armando, Freundlich, Joel S., Sacchettini, James C.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2009
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709434/
https://ncbi.nlm.nih.gov/pubmed/19621084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006290
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