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Hyperactivation of DNA-PK by Double-Strand Break Mimicking Molecules Disorganizes DNA Damage Response

Cellular response to DNA damage involves the coordinated activation of cell cycle checkpoints and DNA repair. The early steps of DNA damage recognition and signaling in mammalian cells are not yet fully understood. To investigate the regulation of the DNA damage response (DDR), we designed short and...

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Autors principals: Quanz, Maria, Chassoux, Danielle, Berthault, Nathalie, Agrario, Céline, Sun, Jian-Sheng, Dutreix, Marie
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709433/
https://ncbi.nlm.nih.gov/pubmed/19621083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006298
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