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Hyperactivation of DNA-PK by Double-Strand Break Mimicking Molecules Disorganizes DNA Damage Response

Cellular response to DNA damage involves the coordinated activation of cell cycle checkpoints and DNA repair. The early steps of DNA damage recognition and signaling in mammalian cells are not yet fully understood. To investigate the regulation of the DNA damage response (DDR), we designed short and...

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Detalhes bibliográficos
Main Authors: Quanz, Maria, Chassoux, Danielle, Berthault, Nathalie, Agrario, Céline, Sun, Jian-Sheng, Dutreix, Marie
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709433/
https://ncbi.nlm.nih.gov/pubmed/19621083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006298
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