The Homocysteine-inducible Endoplasmic Reticulum Stress Protein Counteracts Calcium Store Depletion and Induction of CCAAT Enhancer-binding Protein Homologous Protein in a Neurotoxin Model of Parkinson Disease

The endoplasmic reticulum (ER) is a key organelle regulating intracellular Ca(2+) homeostasis. Oxidants and mitochondria-derived free radicals can target ER-based Ca(2+) regulatory proteins and cause uncontrolled Ca(2+) release that may contribute to protracted ER stress and apoptosis. Several ER st...

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Autors principals: Chigurupati, Srinivasulu, Wei, Zelan, Belal, Cherine, Vandermey, Myriam, Kyriazis, George A., Arumugam, Thiruma V., Chan, Sic L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Mechanisms of Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709401/
https://ncbi.nlm.nih.gov/pubmed/19447887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.020891
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