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Covalent modifiers of Botulinum neurotoxin counteract toxin persistence
Botulinum neurotoxins (BoNTs) are the most potent toxin known to man and a significant threat as a weapon of bioterrorism. BoNTs contain a metalloprotease domain that blocks neurotransmitter release in nerve terminals, resulting in a descending, flaccid paralysis with a 5–10% mortality rate. Existin...
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| Publicado no: | ACS Chem Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7204532/ https://ncbi.nlm.nih.gov/pubmed/30571080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00937 |
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