Numb Endocytic Adapter Proteins Regulate the Transport and Processing of the Amyloid Precursor Protein in an Isoform-dependent Manner: IMPLICATIONS FOR ALZHEIMER DISEASE PATHOGENESIS

Central to the pathogenesis of Alzheimer disease is the aberrant processing of the amyloid precursor protein (APP) to generate amyloid β-peptide (Aβ), the principle component of amyloid plaques. The cell fate determinant Numb is a phosphotyrosine binding domain (PTB)-containing endocytic adapter pro...

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Päätekijät: Kyriazis, George A., Wei, Zelan, Vandermey, Miriam, Jo, Dong-Gyu, Xin, Ouyang, Mattson, Mark P., Chan, Sic L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2008
Aiheet:
Mechanisms of Signal Transduction
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533073/
https://ncbi.nlm.nih.gov/pubmed/18599481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802072200
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