Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer

AIM: To clarify alterations of Dickkopfs (Dkks) and Kremen2 (Krm2) in gastrointestinal cancer. METHODS: We investigated the expression profiles and epigenetic alterations of Dkks and Krm2 genes in gastrointestinal cancer using RT-PCR, tissue microarray analysis, and methylation specific PCR (MSP). C...

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Main Authors: Maehata, Tadateru, Taniguchi, Hiroaki, Yamamoto, Hiroyuki, Nosho, Katsuhiko, Adachi, Yasushi, Miyamoto, Nobuki, Miyamoto, Chie, Akutsu, Noriyuki, Yamaoka, Satoshi, Itoh, Fumio
Formato: Artigo
Idioma:Inglês
Publicado: The WJG Press and Baishideng 2008
Assuntos:
Gastric Cancer
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709050/
https://ncbi.nlm.nih.gov/pubmed/18461655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.14.2702
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