Transcriptional silencing of the Dickkopfs-3 (Dkk-3) gene by CpG hypermethylation in acute lymphoblastic leukaemia

Dkk-3 is a newly characterised mortalisation-related gene and an antagonist of the Wnt oncogenic signalling pathway whose expression is decreased in a variety of cancer cell lines, suggesting that the Dkk-3 gene, located at chromosome 11p15.1, functions as a tumour suppressor gene. Although 11p15 is...

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Detalhes bibliográficos
Main Authors: Roman-Gomez, J, Jimenez-Velasco, A, Agirre, X, Castillejo, J A, Navarro, G, Barrios, M, Andreu, E J, Prosper, F, Heiniger, A, Torres, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
Assuntos:
Molecular and Cellular Pathology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364778/
https://ncbi.nlm.nih.gov/pubmed/15226763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602008
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