Aging of Preleukemic Thymocytes Drives CpG Island Hypermethylation in T-cell Acute Lymphoblastic Leukemia

Cancer cells display DNA hypermethylation at specific CpG islands in comparison with their normal healthy counterparts, but the mechanism that drives this so-called CpG island methylator phenotype (CIMP) remains poorly understood. Here, we show that CpG island methylation in human T-cell acute lymph...

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Pubblicato in:Blood Cancer Discov
Autori principali: Roels, Juliette, Thénoz, Morgan, Szarzyńska, Bronisława, Landfors, Mattias, De Coninck, Stien, Demoen, Lisa, Provez, Lien, Kuchmiy, Anna, Strubbe, Steven, Reunes, Lindy, Pieters, Tim, Matthijssens, Filip, Van Loocke, Wouter, Erarslan-Uysal, Büşra, Richter-Pechańska, Paulina, Declerck, Ken, Lammens, Tim, De Moerloose, Barbara, Deforce, Dieter, Van Nieuwerburgh, Filip, Cheung, Laurence C., Kotecha, Rishi S., Mansour, Marc R., Ghesquière, Bart, Van Camp, Guy, Berghe, Wim Vanden, Kowalczyk, Jerzy R., Szczepański, Tomasz, Davé, Utpal P., Kulozik, Andreas E., Goossens, Steven, Curtis, David J., Taghon, Tom, Dawidowska, Małgorzata, Degerman, Sofie, Van Vlierberghe, Pieter
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for Cancer Research 2020
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116343/
https://ncbi.nlm.nih.gov/pubmed/33179015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2643-3230.BCD-20-0059
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