Aging of Preleukemic Thymocytes Drives CpG Island Hypermethylation in T-cell Acute Lymphoblastic Leukemia

Cancer cells display DNA hypermethylation at specific CpG islands in comparison with their normal healthy counterparts, but the mechanism that drives this so-called CpG island methylator phenotype (CIMP) remains poorly understood. Here, we show that CpG island methylation in human T-cell acute lymph...

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Detalhes bibliográficos
Publicado no:Blood Cancer Discov
Principais autores: Roels, Juliette, Thénoz, Morgan, Szarzyńska, Bronisława, Landfors, Mattias, De Coninck, Stien, Demoen, Lisa, Provez, Lien, Kuchmiy, Anna, Strubbe, Steven, Reunes, Lindy, Pieters, Tim, Matthijssens, Filip, Van Loocke, Wouter, Erarslan-Uysal, Büşra, Richter-Pechańska, Paulina, Declerck, Ken, Lammens, Tim, De Moerloose, Barbara, Deforce, Dieter, Van Nieuwerburgh, Filip, Cheung, Laurence C., Kotecha, Rishi S., Mansour, Marc R., Ghesquière, Bart, Van Camp, Guy, Berghe, Wim Vanden, Kowalczyk, Jerzy R., Szczepański, Tomasz, Davé, Utpal P., Kulozik, Andreas E., Goossens, Steven, Curtis, David J., Taghon, Tom, Dawidowska, Małgorzata, Degerman, Sofie, Van Vlierberghe, Pieter
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for Cancer Research 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116343/
https://ncbi.nlm.nih.gov/pubmed/33179015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2643-3230.BCD-20-0059
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