hsa-miR-20b-5p and hsa-miR-363-3p Affect Expression of PTEN and BIM Tumor Suppressor Genes and Modulate Survival of T-ALL Cells In Vitro

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy arising from T lymphocyte precursors. We have previously shown by miRNA-seq, that miRNAs from the mir-106a-363 cluster are overexpressed in pediatric T-ALL. In silico analysis indicated their potential involvement in the regulat...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Drobna, Monika, Szarzyńska, Bronisława, Jaksik, Roman, Sędek, Łukasz, Kuchmiy, Anna, Taghon, Tom, Van Vlierberghe, Pieter, Szczepański, Tomasz, Witt, Michał, Dawidowska, Małgorzata
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7290785/
https://ncbi.nlm.nih.gov/pubmed/32380791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9051137
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