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Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: Structure-based mechanism of conversion

Mammalian xanthine oxidoreductases, which catalyze the last two steps in the formation of urate, are synthesized as the dehydrogenase form xanthine dehydrogenase (XDH) but can be readily converted to the oxidase form xanthine oxidase (XO) by oxidation of sulfhydryl residues or by proteolysis. Here,...

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Autors principals: Enroth, Cristofer, Eger, Bryan T., Okamoto, Ken, Nishino, Tomoko, Nishino, Takeshi, Pai, Emil F.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC27090/
https://ncbi.nlm.nih.gov/pubmed/11005854
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