Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: Structure-based mechanism of conversion

Mammalian xanthine oxidoreductases, which catalyze the last two steps in the formation of urate, are synthesized as the dehydrogenase form xanthine dehydrogenase (XDH) but can be readily converted to the oxidase form xanthine oxidase (XO) by oxidation of sulfhydryl residues or by proteolysis. Here,...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Enroth, Cristofer, Eger, Bryan T., Okamoto, Ken, Nishino, Tomoko, Nishino, Takeshi, Pai, Emil F.
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27090/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11005854/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.20.10723
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