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BRI3 Inhibits Amyloid Precursor Protein Processing in a Mechanistically Distinct Manner from Its Homologue Dementia Gene BRI2

Alzheimer disease (AD) is characterized by senile plaques, which are mainly composed of β amyloid (Aβ) peptides. Aβ is cleaved off from amyloid precursor protein (APP) with consecutive proteolytic processing: β-secretase, followed by γ-secretase. Here, we show that BRI3, a member of the BRI gene fam...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Matsuda, Shuji, Matsuda, Yukiko, D'Adamio, Luciano
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2009
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708878/
https://ncbi.nlm.nih.gov/pubmed/19366692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.006403
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