BRI3 Inhibits Amyloid Precursor Protein Processing in a Mechanistically Distinct Manner from Its Homologue Dementia Gene BRI2

Antzeko izenburuak

• BRI2 Inhibits Amyloid β-Peptide Precursor Protein Processing by Interfering with the Docking of Secretases to the Substrate
  nork: Matsuda, Shuji, et al.
  Argitaratua: (2008)
• JNK-interacting protein-1 promotes transcription of Aβ protein precursor but not Aβ precursor-like proteins, mechanistically different than Fe65
  nork: Scheinfeld, Meir H., et al.
  Argitaratua: (2003)
• Maturation of BRI2 generates a specific inhibitor that reduces APP processing at the plasma membrane and in endocytic vesicles
  nork: Matsuda, Shuji, et al.
  Argitaratua: (2009)
• APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant
  nork: Tamayev, Robert, et al.
  Argitaratua: (2011)
• Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits
  nork: Tamayev, Robert, et al.
  Argitaratua: (2010)