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BRI3 Inhibits Amyloid Precursor Protein Processing in a Mechanistically Distinct Manner from Its Homologue Dementia Gene BRI2
Alzheimer disease (AD) is characterized by senile plaques, which are mainly composed of β amyloid (Aβ) peptides. Aβ is cleaved off from amyloid precursor protein (APP) with consecutive proteolytic processing: β-secretase, followed by γ-secretase. Here, we show that BRI3, a member of the BRI gene fam...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2708878/ https://ncbi.nlm.nih.gov/pubmed/19366692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.006403 |
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