Elucidating the mechanism of familial amyloidosis– Finnish type: NMR studies of human gelsolin domain 2
Familial amyloidosis–Finnish type (FAF) results from a single mutation at residue 187 (D187N or D187Y) within domain 2 of the actin-regulating protein gelsolin. The mutation somehow allows a masked cleavage site to be exposed, leading to the first step in the formation of an amyloidogenic fragment....
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2000
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27087/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10995458/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.180310097 |
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