Mutations That Increase DNA Binding by the Processivity Factor of Herpes Simplex Virus Affect Virus Production and DNA Replication Fidelity

The interactions of the herpes simplex virus processivity factor UL42 with the catalytic subunit of the viral polymerase (Pol) and DNA are critical for viral DNA replication. Previous studies, including one showing that substitution of glutamine residue 282 with arginine (Q282R) results in an increa...

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Hlavní autoři: Jiang, Changying, Komazin-Meredith, Gloria, Tian, Wang, Coen, Donald M., Hwang, Charles B. C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2009
Témata:
Genome Replication and Regulation of Viral Gene Expression
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708624/
https://ncbi.nlm.nih.gov/pubmed/19474109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00193-09
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