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The Enhanced DNA Replication Fidelity of a Mutant Herpes Simplex Virus Type 1 DNA Polymerase Is Mediated by an Improved Nucleotide Selectivity and Reduced Mismatch Extension Ability

We previously demonstrated that a recombinant herpes simplex virus containing a mutation within the finger domain of DNA polymerase replicated DNA with increased fidelity. In this study, we demonstrate that, compared with wild-type polymerase, the mutant enzyme exhibited improved nucleotide selectiv...

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Detalhes bibliográficos
Main Authors: Tian, Wang, Hwang, Ying T., Hwang, Charles B. C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519654/
https://ncbi.nlm.nih.gov/pubmed/18596099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00911-08
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