Caricamento...

The Enhanced DNA Replication Fidelity of a Mutant Herpes Simplex Virus Type 1 DNA Polymerase Is Mediated by an Improved Nucleotide Selectivity and Reduced Mismatch Extension Ability

We previously demonstrated that a recombinant herpes simplex virus containing a mutation within the finger domain of DNA polymerase replicated DNA with increased fidelity. In this study, we demonstrate that, compared with wild-type polymerase, the mutant enzyme exhibited improved nucleotide selectiv...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Tian, Wang, Hwang, Ying T., Hwang, Charles B. C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519654/
https://ncbi.nlm.nih.gov/pubmed/18596099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00911-08
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !