Finger Domain Mutation Affects Enzyme Activity, DNA Replication Efficiency, and Fidelity of an Exonuclease-Deficient DNA Polymerase of Herpes Simplex Virus Type 1

The catalytic subunit of herpes simplex virus DNA polymerase (Pol), a member of the B family polymerases, possesses both polymerase and exonuclease activities. We previously demonstrated that a recombinant virus (YD12) containing a double mutation within conserved exonuclease motif III of the Pol wa...

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Bibliographic Details
Main Authors: Tian, Wang, Hwang, Ying T., Lu, Qiangsheng, Hwang, Charles B. C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704776/
https://ncbi.nlm.nih.gov/pubmed/19420083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00632-09
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