Coronavirus Genetically Redirected to the Epidermal Growth Factor Receptor Exhibits Effective Antitumor Activity against a Malignant Glioblastoma

Coronaviruses are positive-strand RNA viruses with features attractive for oncolytic therapy. To investigate this potential, we redirected the coronavirus murine hepatitis virus (MHV), which is normally unable to infect human cells, to human tumor cells by using a soluble receptor (soR)-based expres...

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Detalhes bibliográficos
Main Authors: Verheije, Monique H., Lamfers, Martine L. M., Würdinger, Thomas, Grinwis, Guy C. M., Gerritsen, Winald R., van Beusechem, Victor W., Rottier, Peter J. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Gene Delivery
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708613/
https://ncbi.nlm.nih.gov/pubmed/19439466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00495-09
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