The Proteasome Inhibitor Velcade Enhances rather than Reduces Disease in Mouse Hepatitis Coronavirus-Infected Mice

Many viruses, including coronaviruses (CoVs), depend on a functional cellular proteasome for efficient infection in vitro. Hence, the proteasome inhibitor Velcade (bortezomib), a clinically approved anticancer drug, shown in an accompanying study (M. Raaben et al., J. Virol. 84:7869-7879, 2010) to s...

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Bibliografiska uppgifter
Huvudupphovsmän: Raaben, Matthijs, Grinwis, Guy C. M., Rottier, Peter J. M., de Haan, Cornelis A. M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2010
Ämnen:
Pathogenesis and Immunity
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897637/
https://ncbi.nlm.nih.gov/pubmed/20484516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00486-10
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