Chlamydial Heat Shock Protein 60 Induces Acute Pulmonary Inflammation in Mice via the Toll-Like Receptor 4- and MyD88-Dependent Pathway

Heat shock protein 60 derived from Chlamydia pneumoniae (cHSP60) activates Toll-like receptor 4 (TLR4) signaling through the MyD88 pathway in vitro, but it is not known how cHSP60 contributes to C. pneumoniae-induced lung inflammation. We treated wild-type (WT), TLR2(−/−), TLR4(−/−), or MyD88(−/−) m...

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Main Authors: Bulut, Yonca, Shimada, Kenichi, Wong, Michelle H., Chen, Shuang, Gray, Pearl, Alsabeh, Randa, Doherty, Terence M., Crother, Timothy R., Arditi, Moshe
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Host Response and Inflammation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708574/
https://ncbi.nlm.nih.gov/pubmed/19398543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00248-09
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