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An Immunogenic, Surface-Exposed Domain of Haemophilus ducreyi Outer Membrane Protein HgbA Is Involved in Hemoglobin Binding

HgbA is the sole TonB-dependent receptor for hemoglobin (Hb) acquisition of Haemophilus ducreyi. Binding of Hb to HgbA is the initial step in heme acquisition from Hb. To better understand this step, we mutagenized hgbA by deletion of each of the 11 putative surface-exposed loops and expressed each...

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Main Authors: Nepluev, Igor, Afonina, Galyna, Fusco, William G., Leduc, Isabelle, Olsen, Bonnie, Temple, Brenda, Elkins, Christopher
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708535/
https://ncbi.nlm.nih.gov/pubmed/19451245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00034-09
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