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Unusual Role of a Cysteine Residue in Substrate Binding and Activity of Human AP-endonuclease 1
The mammalian AP-endonuclease (APE1) repairs abasic (AP) sites and strand breaks with 3' blocks in the genome that are formed both endogenously and as intermediates during base excision repair (BER). APE1 has an unrelated activity as a redox activator (and named Ref-1) for several trans-acting...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2708089/ https://ncbi.nlm.nih.gov/pubmed/18436236 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.03.052 |
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