MD simulation and experimental evidence for Mg(2+) binding at the B site in human AP endonuclease 1

Apurinic/apyrimidinic endonuclease 1 (APE1), a central enzyme in the base excision repair pathway, cleaves damaged DNA in Mg(2+) dependent reaction. Despite characterization of nine X-ray crystallographic structures of human APE1, in some cases, bound to various metal ions and substrate/product, the...

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Détails bibliographiques
Auteurs principaux: Oezguen, Numan, Mantha, Anil K, Izumi, Tadahide, Schein, Catherine H, Mitra, Sankar, Braun, Werner
Format: Artigo
Langue:Inglês
Publié: Biomedical Informatics 2011
Sujets:
Hypothesis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218521/
https://ncbi.nlm.nih.gov/pubmed/22102776
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