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Unusual Role of a Cysteine Residue in Substrate Binding and Activity of Human AP-endonuclease 1

The mammalian AP-endonuclease (APE1) repairs abasic (AP) sites and strand breaks with 3' blocks in the genome that are formed both endogenously and as intermediates during base excision repair (BER). APE1 has an unrelated activity as a redox activator (and named Ref-1) for several trans-acting...

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Sonraí Bibleagrafaíochta
Main Authors: Mantha, Anil K., Oezguen, Numan, Bhakat, Kishor K., Tadahide, Izumi, Braun, Werner, Mitra, Sankar
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708089/
https://ncbi.nlm.nih.gov/pubmed/18436236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.03.052
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