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Single molecule effects of osteogenesis imperfecta mutations in tropocollagen protein domains
Osteogenesis imperfecta (OI) is a genetic disease characterized by fragile bones, skeletal deformities and, in severe cases, prenatal death that affects more than 1 in 10,000 individuals. Here we show by full atomistic simulation in explicit solvent that OI mutations have a significant influence on...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Wiley Subscription Services, Inc., A Wiley Company
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2708024/ https://ncbi.nlm.nih.gov/pubmed/19177360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.21 |
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