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Single molecule effects of osteogenesis imperfecta mutations in tropocollagen protein domains

Osteogenesis imperfecta (OI) is a genetic disease characterized by fragile bones, skeletal deformities and, in severe cases, prenatal death that affects more than 1 in 10,000 individuals. Here we show by full atomistic simulation in explicit solvent that OI mutations have a significant influence on...

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Autors principals: Gautieri, Alfonso, Vesentini, Simone, Redaelli, Alberto, Buehler, Markus J
Format: Artigo
Idioma:Inglês
Publicat: Wiley Subscription Services, Inc., A Wiley Company 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708024/
https://ncbi.nlm.nih.gov/pubmed/19177360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.21
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