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Hepatocyte necrosis induced by oxidative stress and IL-1α release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis

Hepatocyte IκB kinase β (IKKβ) inhibits hepatocarcinogenesis by suppressing accumulation of reactive oxygen species (ROS) and liver damage, whereas JNK1 activation promotes ROS accumulation, liver damage and carcinogenesis. We examined whether hepatocyte p38α, found to inhibit liver carcinogenesis,...

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Main Authors: Sakurai, Toshiharu, He, Guobin, Matsuzawa, Atsushi, Yu, Guann-Yi, Maeda, Shin, Hardiman, Gary, Karin, Michael
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707922/
https://ncbi.nlm.nih.gov/pubmed/18691550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2008.06.016
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