Induction of the Cytoprotective Enzyme Heme Oxygenase-1 by Statins Is Enhanced in Vascular Endothelium Exposed to Laminar Shear Stress and Impaired by Disturbed Flow

In addition to cholesterol-lowering properties, statins exhibit lipid-independent immunomodulatory, anti-inflammatory actions. However, high concentrations are typically required to induce these effects in vitro, raising questions concerning therapeutic relevance. We present evidence that endothelia...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Ali, Faisal, Zakkar, Mustafa, Karu, Kersti, Lidington, Elaine A., Hamdulay, Shahir S., Boyle, Joseph J., Zloh, Mire, Bauer, Andrea, Haskard, Dorian O., Evans, Paul C., Mason, Justin C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Mechanisms of Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707208/
https://ncbi.nlm.nih.gov/pubmed/19457866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.009886
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge