Induction of the Cytoprotective Enzyme Heme Oxygenase-1 by Statins Is Enhanced in Vascular Endothelium Exposed to Laminar Shear Stress and Impaired by Disturbed Flow

In addition to cholesterol-lowering properties, statins exhibit lipid-independent immunomodulatory, anti-inflammatory actions. However, high concentrations are typically required to induce these effects in vitro, raising questions concerning therapeutic relevance. We present evidence that endothelia...

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Bibliografiska uppgifter
Huvudupphovsmän: Ali, Faisal, Zakkar, Mustafa, Karu, Kersti, Lidington, Elaine A., Hamdulay, Shahir S., Boyle, Joseph J., Zloh, Mire, Bauer, Andrea, Haskard, Dorian O., Evans, Paul C., Mason, Justin C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2009
Ämnen:
Mechanisms of Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707208/
https://ncbi.nlm.nih.gov/pubmed/19457866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.009886
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