Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis

Hypoxia, which leads to dysfunctional cell metabolism, and complement activation both play central roles in the pathogenesis of rheumatoid arthritis (RA). Recent studies have reported that mice deficient for the complement-inhibitory protein CD59 show enhanced susceptibility to antigen-induced arthr...

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Detalhes bibliográficos
Main Authors: Kinderlerer, Anne R, Steinberg, Rivka, Johns, Michael, Harten, Sarah K, Lidington, Elaine A, Haskard, Dorian O, Maxwell, Patrick H, Mason, Justin C
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1779384/
https://ncbi.nlm.nih.gov/pubmed/16859540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2019
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