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Antiangiogenic forms of antithrombin specifically bind to the anticoagulant heparin sequence
A specific pentasaccharide sequence of heparin binds with high affinity to native antithrombin and induces a conformational change in the inhibitor by a previously described two-step interaction mechanism. In this work, the interactions of heparin with the antiangiogenic latent and cleaved antithrom...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2706396/ https://ncbi.nlm.nih.gov/pubmed/19035835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801656u |
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