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Antiangiogenic forms of antithrombin specifically bind to the anticoagulant heparin sequence

A specific pentasaccharide sequence of heparin binds with high affinity to native antithrombin and induces a conformational change in the inhibitor by a previously described two-step interaction mechanism. In this work, the interactions of heparin with the antiangiogenic latent and cleaved antithrom...

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Main Authors: Schedin-Weiss, Sophia, Richard, Benjamin, Hjelm, Rebecka, Olson, Steven T.
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706396/
https://ncbi.nlm.nih.gov/pubmed/19035835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801656u
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