Defective B cell ontogeny and humoral immune response in mice prematurely expressing human complement receptor 2 (CR2, CD21) is similar to that seen in aging wild type mice

Mice prematurely expressing human CR2 (hCR2) in the B cell lineage have a defective B cell ontogeny and humoral immune response. We have previously determined altered tyrosine phosphorylation patterns within hCR2 transgenic mice, suggesting that irreversible changes in B cell signaling pathways had...

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Bibliographic Details
Main Authors: Twohig, Jason P., Pappworth, Isabel Y., Sivasankar, Baalasubramanian, Kulik, Liudmila, Bull, Melanie, Holers, V. Michael, Wang, Eddie C.Y., Marchbank, Kevin J.
Format: Artigo
Language:Inglês
Published: Pergamon Press 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706330/
https://ncbi.nlm.nih.gov/pubmed/19359041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2009.03.007
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