Deficiency of complement receptors CR2/CR1 in Cr2(-/-) mice reduces the extent of secondary brain damage after closed head injury

Complement activation at the C3 convertase level has been associated with acute neuroinflammation and secondary brain injury after severe head trauma. The present study was designed to test the hypothesis that Cr2( -/- ) mice, which lack the receptors CR2/CD21 and CR1/CD35 for complement C3-derived...

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Detalhes bibliográficos
Main Authors: Neher, Miriam D, Rich, Megan C, Keene, Chesleigh N, Weckbach, Sebastian, Bolden, Ashley L, Losacco, Justin T, Patane, Jenée, Flierl, Michael A, Kulik, Liudmila, Holers, V Michael, Stahel, Philip F
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050415/
https://ncbi.nlm.nih.gov/pubmed/24885042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-11-95
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