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A series of cationic sterol lipids with gene transfer and bactericidal activity

A family of cationic lipids was synthesized via direct amide coupling of spermine to the C-24 position of cholic acid analogs. Four monosubstituted spermines and a bis-substituted spermine were evaluated as plasmid transfection reagents, as bacteriostatic agents, and as bactericidal agents. The inco...

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Detalhes bibliográficos
Main Authors: Randazzo, R. A. S., Bucki, R., Janmey, P. A., Diamond, S. L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706119/
https://ncbi.nlm.nih.gov/pubmed/19364656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.03.049
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