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Synthesis and structure-activity relationships of novel cationic lipids with anti-inflammatory and antimicrobial activities

Certain membrane-active cationic steroids are known to also possess both anti-inflammatory and antimicrobial properties. This combined functionality is particularly relevant for potential therapies of infections associated with elevated tissue damage, e.g. cystic fibrosis airway disease, a condition...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Myint, Melissa, Bucki, Robert, Janmey, Paul A., Diamond, Scott L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459899/
https://ncbi.nlm.nih.gov/pubmed/26004577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.04.104
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