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Theoretical site-directed mutagenesis: Asp168Ala mutant of lactate dehydrogenase
Molecular simulations based on the use of hybrid quantum mechanics/molecular mechanics methods are able to provide detailed information about the complex enzymatic reactions and the consequences of specific mutations on the activity of the enzyme. In this work, the reduction of pyruvate to lactate c...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
The Royal Society
2008
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2706108/ https://ncbi.nlm.nih.gov/pubmed/18682365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2008.0211.focus |
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