Llwytho...
Insights on the origin of catalysis on glycine N-methyltransferase from computational modelling
The origin of enzyme catalysis remains a question of debate despite much intense study. We report a QM/MM theoretical study of the S(N)2 methyl transfer reaction catalyzed by a glycine N-methyltransferase (GNMT) and three mutants to test whether recent experimental observations of rate-constant redu...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | J Am Chem Soc |
|---|---|
| Prif Awduron: | , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2018
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6613375/ https://ncbi.nlm.nih.gov/pubmed/29460630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b13655 |
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