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Theoretical site-directed mutagenesis: Asp168Ala mutant of lactate dehydrogenase

Molecular simulations based on the use of hybrid quantum mechanics/molecular mechanics methods are able to provide detailed information about the complex enzymatic reactions and the consequences of specific mutations on the activity of the enzyme. In this work, the reduction of pyruvate to lactate c...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ferrer, Silvia, Tuñón, Iñaki, Moliner, Vicent, Williams, Ian H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Royal Society 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706108/
https://ncbi.nlm.nih.gov/pubmed/18682365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2008.0211.focus
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