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In-vitro Investigation of Oxazol and Urea Analogues of Morphinan at Opioid Receptors

A series of 2-amino-oxazole (7 & 8) analogs and 2-one-oxazole analogs (9 &10) were synthesized from cyclorphan (1) or butorphan (2) and evaluated in-vitro by their binding affinity at μ, δ and κ opioid receptors and compared with their 2-aminothiozole analogs 5 & 6. Ligands 7–10 showed d...

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Hlavní autoři: Peng, Xuemei, Knapp, Brian I., Bidlack, Jean M., Neumeyer, John L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706089/
https://ncbi.nlm.nih.gov/pubmed/17433695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.03.076
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