Measurement of Serum 7α-hydroxy-4-cholesten-3-one (or 7αC4), a Surrogate Test for Bile Acid Malabsorption in Health, Ileal Disease and Irritable Bowel Syndrome using Liquid Chromatography-Tandem Mass Spectrometry

BACKGROUND: Bile acid malabsorption (BAM) is reported in up to 50% of patients with functional diarrhea and irritable bowel syndrome with diarrhea (IBS-D). Serum 7α-hydroxy-4-cholesten-3-one (7αHCO, or 7αC4), an indirect measurement of hepatic bile acid synthesis, has been validated as a measurement...

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Autori principali: Camilleri, Michael, Nadeau, Ashley, Tremaine, William J., Lamsam, Jesse, Burton, Duane, Odunsi, Suwebatu, Sweetser, Seth, Singh, Ravinder
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2705747/
https://ncbi.nlm.nih.gov/pubmed/19368662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2982.2009.01288.x
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